Vanessa and her oldest daughter Kai were photographed as they left a pharmacy, with the mother at one point reaching over and putting her arms around the 10-year-old girl as they headed home.
She and Don Jr. have been married for 13 years and have five children – Kai (10), Donald III (9), Tristan (7), Spencer (5) and Chloe (3).
Vanessa and Don Jr have yet to respond to requests for comment.
Out and about: Vanessa Trump was seen for the first time since Page Six reported that friends believe she and Donald Trump Jr will soon file for divorce
Helping hand: At one point Vanessa reached over and put her arm around Kai (above) as they headed back to the family’s apartment
Nothing to say: Both Don Jr and Vanessa have not responded to requests for comment (Vanessa above on Wednesday)
Wedded bliss: The couple was married in 2005 at Mar-a-Lago and had five children during the first 9 years of their marriage (l to r: Eric, Ivanka, Donald, Vanessa and Veronika Haydon)
Cake by the ocean: The family was last seen together in February when they all celebrated Don III birthday in Palm Beach (above)
Page Six reports that sources close to the pair have said that the two are leading separate lives, and have been for some time.
‘The problems have been there for a long time, the couple had hoped to stay together during the president’s time in office, but it is getting harder to resolve their issues,’ said one source.
‘He’s never there.’
The two have been spotted together less and less in recent months, and spent almost no time with one another over the holidays at Mar-a-Lago.
Don Jr posted a number of videos to social media during the two weeks that the pair were in Palm Beach which showed him with the couple’s children but never Vanessa.
Vanessa was also absent from one of the family dinners and did not attend the annual New Year’s Eve gala, with Don Jr. instead taking his son Donnie.
It was also his birthday that night.
Then, in February, it was revealed that Vanessa was at an apartment a few blocks away from the family’s residence in Manhattan when she opened a letter addressed to her husband containing a mystery white powder.
In the wake of those reports, the two were seen together on February 13 doing the school run with their two youngest children, Chloe and Spencer.
A week later, the entire family traveled down to Mar-a-Lago for Donnie’s birthday.
Don Jr posted a photo of that to Instagram which showed everyone smiling for the camera, writing: ‘Happy birthday Donnie. Some birthday cake for my 9 year old little man yesterday. Somehow I hit send then but it didn’t go through.’
Just before that trip however, Don Jr spent Valentine’s Day with another lady – his daughter Kai.
‘Valentine’s Day selfie with one of my favorite Valentines. Early dinner with my girl Kai,’ wrote Don Jr on Instagram.
Vanessa meanwhile was spotted out to eat with her sons Donnie and Tristan.
Date night: The couple has only been seen together twice this year, and Don Jr spent Valentine’s Day with daughter Kai (above) while Vanessa took out two of their sons
Sister, sister: Vanessa was also not with Don Jr on his birthday, which is also New Year’s Eve, with President Trump’s oldest son instead going out with son Donnie (Don jr and Ivanka on his birthday at Mar-a-Lago)
Happier times: The pair were all smiles on a family vacation to Aspen last march, but left early when their son Tristan broke his leg (Don Jr, Ivanka and Vanessa in Aspen)
MIA: Vanessa did not attend the State of the Union in Washington DC, though that may have had more to do with her children being in school at the time
The couple had been introduced multiple times by friends hoping to set them up before going on their first date.
Don Jr proposed to Vanessa, who was a model and actress at the time, with a $100,000 engagement ring back in 2004.
The proposal was captured by the multiple photographers alerted to the fact that Don Jr would be proposing in front of the same jewelry store from which he obtained the ring for a heavily discounted price.
They were married at Mar-a-Lago in November 2005, though those plans were almost derailed due to Hurricane Wilma, which forced the couple to move the wedding from the club’s lawn to a more sheltered space by the pool due to the damage done by high winds.
Those nuptials took a backseat in the press however to the fact that the wedding marked one of the rare occasions when Donald and his new wife Melania cake face-to-face with his ex Ivana.
Photos from the event show Donald and Melania smiling in the front row while Ivana looks less than pleased to have her picture taken as she sits next to her mother Marie.
United front: Don Jr and Vanessa were seen doing the school run with daughter Chloe and son Tristan on February 13 (above)
Tough time: Friends claim that things became difficult for the couple in the wake of President Trump’s win in the 2016 presidential election (l to r: Mike Pence, Donald Trump, Ivanka Trump, Jared Kushner and Vanessa in July 2016)
Vanessa was very much in the spotlight prior to the couple’s wedding, but after that began to focus on her children.
She gave birth to all five of the couple’s children in a span of just seven years.
In the wake of her father-in-law’s announcement that he would be running for president, Vanessa did step out on the campaign trail a bit, and occasionally post on social media.
Vanessa also may have provided the first clue that she and Don Jr were leading separate lives back in November when she posted a photo of her Christmas tree of Twitter and wrote: I just finished decorating our tree with my kiddies ! We are in the holiday spirit! Christmas will be here soon!’
There was no mention of her husband at all in the tweet.
She last posted a tweet that showed her with Don Jr back in June for President Trump’s birthday.
News of the divorce follows a difficult Tuesday for Don Jr, who was campaigning for Rick Saccone in Pennsylvania.
Saccone has not lost that race at this time but is behind Democrat Conor Lamb.